ea0063gp180 | Benign Thyroid Disorders | ECE2019
Gonzalez-Guerrero Cristian
, Borso Marco
, Garcia-Gimenez Jorge
, Salas-Lucia Federico
, Alikhani Pouya
, Saba Alessandro
, Zucchi Riccardo
, Moreno Jose C
Thyroid hormone (TH) synthesis requires iodine, a scarce element whose recycling is mediated by DEHAL1 through deiodination of iodotyrosines MIT and DIT. In humans, DEHAL1 defects lead to severe congenital hypothyroidism (CH) non-detected by neonatal screening programs, which involves the risk of mental retardation in infants. The timing for establishment of this hypothyroidism remains unknown, but environmental iodine deficiency may represent a triggering factor. Whi...